/* ============================================================
   DESIGN TOKENS
   ============================================================ */
:root {
  /* Type scale */
  --text-xs:   clamp(0.75rem, 0.7rem + 0.25vw, 0.875rem);
  --text-sm:   clamp(0.875rem, 0.8rem + 0.35vw, 1rem);
  --text-base: clamp(1rem, 0.95rem + 0.25vw, 1.125rem);
  --text-lg:   clamp(1.125rem, 1rem + 0.75vw, 1.5rem);
  --text-xl:   clamp(1.5rem, 1.2rem + 1.25vw, 2.25rem);
  --text-2xl:  clamp(2rem, 1.2rem + 2.5vw, 3.5rem);
  --text-3xl:  clamp(2.5rem, 1rem + 5vw, 5.5rem);
  --text-hero: clamp(3.5rem, 2rem + 7vw, 8.5rem);

  /* Spacing */
  --space-1: 0.25rem;  --space-2: 0.5rem;   --space-3: 0.75rem;
  --space-4: 1rem;     --space-5: 1.25rem;  --space-6: 1.5rem;
  --space-8: 2rem;     --space-10: 2.5rem;  --space-12: 3rem;
  --space-16: 4rem;    --space-20: 5rem;    --space-24: 6rem;
  --space-32: 8rem;

  /* Content widths */
  --content-narrow: 640px;
  --content-default: 960px;
  --content-wide: 1200px;

  /* Radius */
  --radius-sm: 0.375rem;  --radius-md: 0.5rem;
  --radius-lg: 0.75rem;   --radius-xl: 1rem;
  --radius-full: 9999px;

  /* Transitions */
  --ease-out: cubic-bezier(0.16,1,0.3,1);
  --ease-in:  cubic-bezier(0.4,0,1,1);
  --ease-inout: cubic-bezier(0.4,0,0.2,1);

  /* Fonts */
  --font-display: 'Instrument Serif', Georgia, serif;
  --font-body: 'Satoshi', 'Inter', system-ui, sans-serif;

  /* Brand accent */
  --color-accent: #12B5C3;
  --color-accent-hover: #0E9DAB;
  --color-accent-dim: rgba(18,181,195,0.15);
  --color-accent-dim2: rgba(18,181,195,0.08);
}

/* ============================================================
   LIGHT MODE (Light sections)
   ============================================================ */
:root, [data-theme='light'] {
  --color-bg: #F7F9FC;
  --color-surface: #FFFFFF;
  --color-surface-2: #F0F4F8;
  --color-border: rgba(15,24,41,0.09);
  --color-text: #0F1829;
  --color-text-muted: #5B6B82;
  --color-text-faint: #9AAABB;
  /* Dark section specific */
  --dark-bg: #0B1629;
  --dark-surface: rgba(255,255,255,0.04);
  --dark-surface-hover: rgba(255,255,255,0.07);
  --dark-border: rgba(228,236,244,0.1);
  --dark-text: #E4ECF4;
  --dark-text-muted: rgba(228,236,244,0.55);
  --dark-text-faint: rgba(228,236,244,0.3);
  /* Shadows */
  --shadow-sm: 0 1px 3px rgba(15,24,41,0.06), 0 1px 2px rgba(15,24,41,0.04);
  --shadow-md: 0 4px 12px rgba(15,24,41,0.08), 0 2px 4px rgba(15,24,41,0.05);
  --shadow-lg: 0 12px 32px rgba(15,24,41,0.1), 0 4px 12px rgba(15,24,41,0.06);
}

/* ============================================================
   DARK MODE
   ============================================================ */
[data-theme='dark'] {
  --color-bg: #0D1A2B;
  --color-surface: #0F1E30;
  --color-surface-2: #142235;
  --color-border: rgba(228,236,244,0.09);
  --color-text: #D8E6F0;
  --color-text-muted: #7A9AB5;
  --color-text-faint: #4A6880;
  /* Dark sections become slightly different dark in dark mode */
  --dark-bg: #07111E;
  --dark-surface: rgba(255,255,255,0.04);
  --dark-surface-hover: rgba(255,255,255,0.07);
  --dark-border: rgba(228,236,244,0.1);
  --dark-text: #E4ECF4;
  --dark-text-muted: rgba(228,236,244,0.55);
  --dark-text-faint: rgba(228,236,244,0.3);
  --shadow-sm: 0 1px 3px rgba(0,0,0,0.25);
  --shadow-md: 0 4px 12px rgba(0,0,0,0.35);
  --shadow-lg: 0 12px 32px rgba(0,0,0,0.45);
}

@media (prefers-color-scheme: dark) {
  :root:not([data-theme]) {
    --color-bg: #0D1A2B;
    --color-surface: #0F1E30;
    --color-surface-2: #142235;
    --color-border: rgba(228,236,244,0.09);
    --color-text: #D8E6F0;
    --color-text-muted: #7A9AB5;
    --color-text-faint: #4A6880;
    --dark-bg: #07111E;
    --shadow-sm: 0 1px 3px rgba(0,0,0,0.25);
    --shadow-md: 0 4px 12px rgba(0,0,0,0.35);
    --shadow-lg: 0 12px 32px rgba(0,0,0,0.45);
  }
}

/* ============================================================
   SECTION SYSTEM
   ============================================================ */
.section-light {
  background: var(--color-bg);
  color: var(--color-text);
}

.section-dark {
  background: var(--dark-bg);
  color: var(--dark-text);
}

.section-pad {
  padding-block: clamp(var(--space-16), 8vw, var(--space-32));
  padding-inline: clamp(var(--space-4), 4vw, var(--space-8));
}

/* ============================================================
   LAYOUT
   ============================================================ */
.container {
  max-width: var(--content-wide);
  margin-inline: auto;
  padding-inline: clamp(var(--space-4), 4vw, var(--space-12));
}

.container--narrow {
  max-width: var(--content-default);
  margin-inline: auto;
  padding-inline: clamp(var(--space-4), 4vw, var(--space-8));
}

/* ============================================================
   TYPOGRAPHY UTILITY
   ============================================================ */
.eyebrow {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 600;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--color-accent);
}

.section-title {
  font-family: var(--font-display);
  font-size: var(--text-2xl);
  font-weight: 400;
  line-height: 1.1;
  font-style: italic;
}

.section-title em {
  font-style: normal;
  color: var(--color-accent);
}

.section-body {
  font-family: var(--font-body);
  font-size: var(--text-base);
  color: var(--color-text-muted);
  line-height: 1.7;
}

.section-dark .section-body {
  color: var(--dark-text-muted);
}

/* ============================================================
   BUTTONS
   ============================================================ */
.btn {
  display: inline-flex;
  align-items: center;
  gap: var(--space-2);
  padding: var(--space-3) var(--space-6);
  border-radius: var(--radius-full);
  font-family: var(--font-body);
  font-size: var(--text-sm);
  font-weight: 600;
  letter-spacing: 0.01em;
  text-decoration: none;
  cursor: pointer;
  white-space: nowrap;
  transition: background 180ms var(--ease-out), color 180ms var(--ease-out),
              box-shadow 180ms var(--ease-out), transform 180ms var(--ease-out),
              border-color 180ms var(--ease-out);
}

.btn:hover { transform: translateY(-1px); }
.btn:active { transform: translateY(0); }

.btn-primary {
  background: var(--color-accent);
  color: #fff;
  border: 2px solid var(--color-accent);
}
.btn-primary:hover {
  background: var(--color-accent-hover);
  border-color: var(--color-accent-hover);
  box-shadow: 0 4px 20px rgba(18,181,195,0.35);
}

.btn-outline {
  background: transparent;
  color: var(--dark-text);
  border: 2px solid rgba(228,236,244,0.35);
}
.btn-outline:hover {
  border-color: var(--color-accent);
  color: var(--color-accent);
}

.btn-outline-dark {
  background: transparent;
  color: var(--color-text);
  border: 2px solid var(--color-border);
}
.btn-outline-dark:hover {
  border-color: var(--color-accent);
  color: var(--color-accent);
}

.btn-sm {
  padding: var(--space-2) var(--space-4);
  font-size: var(--text-xs);
}

/* ============================================================
   BADGE
   ============================================================ */
.badge {
  display: inline-flex;
  align-items: center;
  gap: var(--space-2);
  padding: var(--space-1) var(--space-3);
  background: var(--color-accent-dim);
  border: 1px solid rgba(18,181,195,0.3);
  border-radius: var(--radius-full);
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--color-accent);
}

.badge::before {
  content: '';
  display: block;
  width: 6px;
  height: 6px;
  border-radius: 50%;
  background: var(--color-accent);
  flex-shrink: 0;
}

/* ============================================================
   NAVIGATION
   ============================================================ */
.nav {
  position: fixed;
  top: 0;
  left: 0;
  right: 0;
  z-index: 100;
  transition: background 300ms var(--ease-out), box-shadow 300ms var(--ease-out),
              transform 300ms var(--ease-out);
}

.nav.scrolled {
  background: rgba(11,22,41,0.92);
  backdrop-filter: blur(16px);
  -webkit-backdrop-filter: blur(16px);
  box-shadow: 0 1px 0 rgba(228,236,244,0.08);
}

.nav.hidden { transform: translateY(-100%); }

.nav.menu-open {
  background: rgba(11,22,41,0.97);
  backdrop-filter: blur(16px);
  -webkit-backdrop-filter: blur(16px);
  box-shadow: 0 1px 0 rgba(228,236,244,0.08);
}

.nav-inner {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: var(--space-6);
  padding-block: var(--space-4);
}

.nav-logo {
  display: flex;
  align-items: center;
  gap: var(--space-3);
  text-decoration: none;
  color: #E4ECF4;
  flex-shrink: 0;
}

.nav-logo-icon { width: 36px; height: 36px; }

.nav-logo-text {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  line-height: 1.2;
}

.nav-logo-text small {
  display: block;
  font-size: 0.65em;
  font-weight: 400;
  letter-spacing: 0.04em;
  opacity: 0.55;
  text-transform: uppercase;
}

.nav-links {
  display: flex;
  align-items: center;
  gap: var(--space-8);
  list-style: none;
}

.nav-links a {
  text-decoration: none;
  font-family: var(--font-body);
  font-size: var(--text-sm);
  font-weight: 500;
  color: rgba(228,236,244,0.7);
  transition: color 180ms var(--ease-out);
}

.nav-links a:hover { color: #E4ECF4; }

.nav-actions {
  display: flex;
  align-items: center;
  gap: var(--space-3);
}

.theme-toggle {
  display: flex;
  align-items: center;
  justify-content: center;
  width: 36px;
  height: 36px;
  border-radius: var(--radius-full);
  color: rgba(228,236,244,0.6);
  background: transparent;
  border: none;
  cursor: pointer;
  transition: color 180ms var(--ease-out), background 180ms var(--ease-out);
}
.theme-toggle:hover {
  color: #E4ECF4;
  background: rgba(228,236,244,0.08);
}

.nav-hamburger {
  display: none;
  flex-direction: column;
  justify-content: center;
  gap: 5px;
  width: 36px;
  height: 36px;
  padding: var(--space-2);
  cursor: pointer;
  background: none;
  border: none;
  color: rgba(228,236,244,0.8);
}
.nav-hamburger span {
  display: block;
  height: 2px;
  background: currentColor;
  border-radius: 2px;
  transition: all 300ms var(--ease-out);
}

.nav-mobile {
  display: none;
  flex-direction: column;
  gap: var(--space-2);
  padding: var(--space-4) 0 var(--space-6);
  border-top: 1px solid rgba(228,236,244,0.08);
  margin-top: var(--space-2);
}
.nav-mobile.open { display: flex; }
.nav-mobile a {
  text-decoration: none;
  font-family: var(--font-body);
  font-size: var(--text-base);
  font-weight: 500;
  color: rgba(228,236,244,0.7);
  padding-block: var(--space-3);
  transition: color 180ms var(--ease-out);
}
.nav-mobile a:hover { color: #E4ECF4; }

@media (max-width: 768px) {
  .nav-links, .nav-actions .btn { display: none; }
  .nav-hamburger { display: flex; }
  .theme-toggle { display: flex; }
}

/* ============================================================
   HERO
   ============================================================ */
.hero {
  position: relative;
  min-height: 100dvh;
  display: flex;
  align-items: center;
  overflow: hidden;
  background: var(--dark-bg);
}

.hero-bg {
  position: absolute;
  inset: 0;
  z-index: 0;
}

.hero-bg img {
  width: 100%;
  height: 100%;
  object-fit: cover;
  object-position: center;
  opacity: 0.35;
}

.hero-overlay {
  position: absolute;
  inset: 0;
  background: 
    linear-gradient(135deg, rgba(11,22,41,0.85) 0%, rgba(11,22,41,0.5) 60%, rgba(11,22,41,0.2) 100%),
    linear-gradient(to bottom, rgba(11,22,41,0.3) 0%, rgba(11,22,41,0.95) 100%);
}

.hero-content {
  position: relative;
  z-index: 1;
  padding-block: clamp(var(--space-24), 10vw, var(--space-32));
  max-width: 820px;
}

.hero-content .badge { margin-bottom: var(--space-8); }

.hero-title {
  font-family: var(--font-display);
  font-size: var(--text-hero);
  font-weight: 400;
  line-height: 0.95;
  color: #E4ECF4;
  margin-bottom: var(--space-8);
  letter-spacing: -0.02em;
}

.hero-title em {
  display: block;
  font-style: italic;
  color: var(--color-accent);
}

.hero-sub {
  font-family: var(--font-body);
  font-size: clamp(1.1rem, 1rem + 0.5vw, 1.375rem);
  line-height: 1.6;
  color: rgba(228,236,244,0.75);
  max-width: 580px;
  margin-bottom: var(--space-8);
}

.hero-specs {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: var(--space-2) var(--space-4);
  margin-bottom: var(--space-10);
}

.hero-specs span {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 600;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: rgba(228,236,244,0.45);
}

.hero-specs .sep {
  color: var(--color-accent);
  opacity: 0.4;
  font-size: 1rem;
}

.hero-ctas {
  display: flex;
  flex-wrap: wrap;
  gap: var(--space-3);
}

.hero-scroll {
  position: absolute;
  bottom: var(--space-8);
  left: 50%;
  transform: translateX(-50%);
  z-index: 1;
  display: flex;
  flex-direction: column;
  align-items: center;
  gap: var(--space-2);
  color: rgba(228,236,244,0.3);
  font-family: var(--font-body);
  font-size: var(--text-xs);
  letter-spacing: 0.08em;
  text-transform: uppercase;
  cursor: default;
  animation: scrollBounce 2s ease-in-out infinite;
}

.hero-scroll svg {
  animation: scrollBounce 2s ease-in-out infinite;
}

@keyframes scrollBounce {
  0%, 100% { transform: translateY(0); opacity: 0.3; }
  50% { transform: translateY(4px); opacity: 0.6; }
}

/* ============================================================
   METRICS BAR
   ============================================================ */
.metrics {
  background: var(--color-surface);
  border-block: 1px solid var(--color-border);
  padding-block: clamp(var(--space-10), 5vw, var(--space-16));
}

.metrics-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
  gap: var(--space-8) var(--space-10);
  align-items: start;
}

.metric {
  text-align: center;
  padding-inline: var(--space-4);
}

.metric-number {
  font-family: var(--font-display);
  font-size: var(--text-2xl);
  font-weight: 400;
  color: var(--color-accent);
  line-height: 1;
  margin-bottom: var(--space-2);
  letter-spacing: -0.02em;
}

.metric-label {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 500;
  color: var(--color-text-muted);
  line-height: 1.4;
  letter-spacing: 0.02em;
  max-width: 20ch;
  margin-inline: auto;
}

/* ============================================================
   PROBLEM SECTION
   ============================================================ */
.problem-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: clamp(var(--space-8), 5vw, var(--space-16));
  align-items: start;
  margin-top: var(--space-12);
}

.problem-col-header {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--color-accent);
  margin-bottom: var(--space-4);
}

.problem-col h3 {
  font-family: var(--font-display);
  font-size: var(--text-lg);
  font-weight: 400;
  color: var(--dark-text);
  margin-bottom: var(--space-4);
  line-height: 1.3;
}

.problem-col p {
  font-family: var(--font-body);
  font-size: var(--text-base);
  color: var(--dark-text-muted);
  line-height: 1.7;
  margin-bottom: var(--space-4);
  max-width: none;
}

.biomarker-list {
  list-style: none;
  display: flex;
  flex-direction: column;
  gap: var(--space-3);
  margin-top: var(--space-6);
}

.biomarker-list li {
  display: flex;
  align-items: flex-start;
  gap: var(--space-3);
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: var(--dark-text-muted);
  max-width: none;
}

.biomarker-list li::before {
  content: '↑';
  color: var(--color-accent);
  font-size: var(--text-xs);
  font-weight: 700;
  margin-top: 2px;
  flex-shrink: 0;
}

.citation-note {
  margin-top: var(--space-8);
  padding: var(--space-4) var(--space-5);
  background: var(--dark-surface);
  border-left: 3px solid var(--color-accent);
  border-radius: 0 var(--radius-md) var(--radius-md) 0;
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--dark-text-faint);
  font-style: italic;
}

.citation-note strong { color: var(--dark-text-muted); font-style: normal; }

@media (max-width: 640px) {
  .problem-grid { grid-template-columns: 1fr; }
}

/* ============================================================
   SOLUTION SECTION
   ============================================================ */
.solution-intro {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: clamp(var(--space-8), 6vw, var(--space-20));
  align-items: center;
  margin-bottom: clamp(var(--space-16), 8vw, var(--space-24));
}

.solution-image-wrap {
  border-radius: var(--radius-xl);
  overflow: hidden;
  box-shadow: var(--shadow-lg);
  position: relative;
}

.solution-image-wrap img {
  width: 100%;
  aspect-ratio: 4/3;
  object-fit: cover;
}

.pillars {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: var(--space-6);
  margin-bottom: clamp(var(--space-16), 8vw, var(--space-24));
}

.pillar {
  padding: var(--space-8) var(--space-6);
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius-xl);
  box-shadow: var(--shadow-sm);
  transition: box-shadow 200ms var(--ease-out), transform 200ms var(--ease-out);
}

.pillar:hover {
  box-shadow: var(--shadow-md);
  transform: translateY(-2px);
}

.pillar-icon {
  width: 44px;
  height: 44px;
  background: var(--color-accent-dim);
  border-radius: var(--radius-lg);
  display: flex;
  align-items: center;
  justify-content: center;
  margin-bottom: var(--space-4);
  color: var(--color-accent);
}

.pillar h3 {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  font-weight: 700;
  color: var(--color-text);
  margin-bottom: var(--space-2);
  letter-spacing: 0.01em;
}

.pillar p {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: var(--color-text-muted);
  line-height: 1.6;
}

/* Comparison table */
.comparison-wrap {
  overflow-x: auto;
  border-radius: var(--radius-xl);
  box-shadow: var(--shadow-md);
  border: 1px solid var(--color-border);
}

.comparison-table {
  width: 100%;
  border-collapse: collapse;
  font-family: var(--font-body);
  font-size: var(--text-sm);
  background: var(--color-surface);
}

.comparison-table th {
  padding: var(--space-4) var(--space-6);
  text-align: left;
  font-weight: 700;
  font-size: var(--text-xs);
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--color-text-muted);
  background: var(--color-surface-2);
  border-bottom: 1px solid var(--color-border);
}

.comparison-table th.lucid-col {
  background: var(--color-accent-dim);
  color: var(--color-accent);
  border-color: rgba(18,181,195,0.2);
}

.comparison-table td {
  padding: var(--space-3) var(--space-6);
  color: var(--color-text);
  border-bottom: 1px solid var(--color-border);
  vertical-align: middle;
  line-height: 1.5;
}

.comparison-table tr:last-child td { border-bottom: none; }

.comparison-table td:first-child {
  font-weight: 600;
  font-size: var(--text-xs);
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--color-text-muted);
  white-space: nowrap;
  background: var(--color-surface-2);
}

.comparison-table td.lucid-col {
  background: var(--color-accent-dim2);
  color: var(--color-accent);
  font-weight: 600;
}

.comparison-table tr:hover td:not(.lucid-col):not(:first-child) {
  background: var(--color-surface-2);
}

@media (max-width: 768px) {
  .solution-intro { grid-template-columns: 1fr; }
  .pillars { grid-template-columns: 1fr; }
  .solution-image-wrap { display: none; }
}
@media (max-width: 900px) {
  .pillars { grid-template-columns: 1fr 1fr; }
}

/* ============================================================
   CLINICAL ROADMAP
   ============================================================ */
.timeline {
  margin-top: var(--space-16);
  position: relative;
}

.timeline::before {
  content: '';
  position: absolute;
  left: 28px;
  top: 0;
  bottom: 0;
  width: 2px;
  background: linear-gradient(to bottom, var(--color-accent), rgba(18,181,195,0.15));
}

.timeline-item {
  display: flex;
  gap: var(--space-8);
  align-items: flex-start;
  margin-bottom: var(--space-10);
  position: relative;
}

.timeline-item:last-child { margin-bottom: 0; }

.timeline-node {
  width: 58px;
  height: 58px;
  border-radius: 50%;
  display: flex;
  align-items: center;
  justify-content: center;
  flex-shrink: 0;
  position: relative;
  z-index: 1;
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  border: 2px solid var(--dark-border);
  background: var(--dark-bg);
  color: var(--dark-text-faint);
  transition: border-color 200ms, color 200ms;
}

.timeline-node.completed {
  background: var(--color-accent);
  border-color: var(--color-accent);
  color: #fff;
  box-shadow: 0 0 20px rgba(18,181,195,0.4);
}

.timeline-node.active {
  border-color: var(--color-accent);
  color: var(--color-accent);
  box-shadow: 0 0 0 6px rgba(18,181,195,0.1);
}

.timeline-content {
  padding-top: var(--space-3);
  padding-bottom: var(--space-8);
  flex: 1;
}

.timeline-date {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 600;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--color-accent);
  margin-bottom: var(--space-1);
}

.timeline-title {
  font-family: var(--font-body);
  font-size: var(--text-lg);
  font-weight: 700;
  color: var(--dark-text);
  margin-bottom: var(--space-2);
  line-height: 1.3;
}

.timeline-desc {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: var(--dark-text-muted);
  line-height: 1.6;
  max-width: 55ch;
}

.timeline-status {
  display: inline-flex;
  align-items: center;
  gap: var(--space-1);
  margin-top: var(--space-2);
  font-size: var(--text-xs);
  font-weight: 600;
  color: var(--color-accent);
  background: var(--color-accent-dim);
  border-radius: var(--radius-full);
  padding: 2px 10px;
}

.safety-callout {
  margin-top: var(--space-16);
  padding: var(--space-8);
  background: var(--dark-surface);
  border: 1px solid var(--dark-border);
  border-top: 3px solid var(--color-accent);
  border-radius: var(--radius-xl);
  display: grid;
  grid-template-columns: auto 1fr;
  gap: var(--space-6);
  align-items: start;
}

.safety-icon {
  width: 48px;
  height: 48px;
  background: var(--color-accent-dim);
  border-radius: var(--radius-lg);
  display: flex;
  align-items: center;
  justify-content: center;
  color: var(--color-accent);
  flex-shrink: 0;
}

.safety-callout h4 {
  font-family: var(--font-body);
  font-size: var(--text-base);
  font-weight: 700;
  color: var(--dark-text);
  margin-bottom: var(--space-2);
}

.safety-callout p {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: var(--dark-text-muted);
  line-height: 1.6;
  max-width: none;
}

@media (max-width: 640px) {
  .timeline::before { left: 20px; }
  .timeline-node { width: 42px; height: 42px; font-size: 0.6rem; }
  .safety-callout { grid-template-columns: 1fr; }
}

/* ============================================================
   SCIENCE / CITATIONS
   ============================================================ */
.citations-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
  gap: var(--space-6);
  margin-top: var(--space-12);
}

.citation-card {
  padding: var(--space-6);
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius-xl);
  box-shadow: var(--shadow-sm);
  display: flex;
  flex-direction: column;
  gap: var(--space-3);
  transition: box-shadow 200ms var(--ease-out), transform 200ms var(--ease-out);
}

.citation-card:hover {
  box-shadow: var(--shadow-md);
  transform: translateY(-2px);
}

.citation-journal {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--color-accent);
}

.citation-title {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  font-weight: 700;
  color: var(--color-text);
  line-height: 1.4;
}

.citation-authors {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--color-text-muted);
  font-style: italic;
}

.citation-relevance {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: var(--color-text-muted);
  line-height: 1.6;
  flex: 1;
  max-width: none;
}

.citation-link {
  display: inline-flex;
  align-items: center;
  gap: var(--space-1);
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 600;
  color: var(--color-accent);
  text-decoration: none;
  margin-top: auto;
}

.citation-link:hover { text-decoration: underline; }

/* ============================================================
   TEAM
   ============================================================ */
.team-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: clamp(var(--space-8), 5vw, var(--space-16));
  margin-top: var(--space-12);
}

.team-founder {
  grid-column: 1 / -1;
  display: grid;
  grid-template-columns: 220px 1fr;
  gap: var(--space-8);
  align-items: start;
  padding: var(--space-8);
  background: var(--dark-surface);
  border: 1px solid var(--dark-border);
  border-radius: var(--radius-xl);
}

.team-avatar {
  width: 100%;
  aspect-ratio: 1;
  border-radius: var(--radius-lg);
  object-fit: cover;
  background: rgba(18,181,195,0.1);
  display: flex;
  align-items: center;
  justify-content: center;
  overflow: hidden;
}

.team-avatar-placeholder {
  width: 100%;
  aspect-ratio: 1;
  border-radius: var(--radius-lg);
  background: linear-gradient(135deg, rgba(18,181,195,0.12), rgba(18,181,195,0.06));
  display: flex;
  align-items: center;
  justify-content: center;
  color: rgba(18,181,195,0.35);
  border: 1px solid rgba(18,181,195,0.15);
}

.team-info { padding-top: var(--space-2); }

.team-role {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--color-accent);
  margin-bottom: var(--space-2);
}

.team-name {
  font-family: var(--font-display);
  font-size: var(--text-xl);
  font-weight: 400;
  color: var(--dark-text);
  margin-bottom: var(--space-4);
  line-height: 1.2;
}

.team-bio {
  font-family: var(--font-body);
  font-size: var(--text-base);
  color: var(--dark-text-muted);
  line-height: 1.7;
  max-width: none;
}

.advisors-section { grid-column: 1 / -1; margin-top: var(--space-4); }

.advisors-label {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--dark-text-faint);
  margin-bottom: var(--space-6);
}

.advisors-grid {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: var(--space-4);
}

.advisor-slot {
  padding: var(--space-5);
  background: var(--dark-surface);
  border: 1px dashed rgba(228,236,244,0.12);
  border-radius: var(--radius-lg);
  text-align: center;
}

.advisor-slot p {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--dark-text-faint);
  font-style: italic;
  line-height: 1.5;
  max-width: none;
}

@media (max-width: 768px) {
  .team-founder { grid-template-columns: 1fr; }
  .team-avatar-placeholder { max-width: 120px; }
  .advisors-grid { grid-template-columns: 1fr; }
  .team-grid { grid-template-columns: 1fr; }
}

/* ============================================================
   INVESTORS
   ============================================================ */
.investors-intro {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: clamp(var(--space-8), 6vw, var(--space-16));
  align-items: start;
  margin-bottom: var(--space-16);
}

.market-stats {
  display: flex;
  flex-direction: column;
  gap: var(--space-6);
}

.market-stat {
  display: flex;
  gap: var(--space-4);
  align-items: flex-start;
}

.market-stat-bar {
  width: 4px;
  align-self: stretch;
  background: var(--color-accent);
  border-radius: var(--radius-full);
  flex-shrink: 0;
  min-height: 40px;
}

.market-stat-value {
  font-family: var(--font-display);
  font-size: var(--text-xl);
  font-weight: 400;
  color: var(--color-accent);
  line-height: 1.1;
  margin-bottom: var(--space-1);
}

.market-stat-desc {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: var(--color-text-muted);
  line-height: 1.5;
  max-width: none;
}

.contact-tracks {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: var(--space-6);
}

.contact-track {
  padding: var(--space-8);
  border-radius: var(--radius-xl);
  border: 1px solid var(--dark-border);
  background: var(--dark-surface);
  box-shadow: 0 1px 3px rgba(0,0,0,0.3);
  display: flex;
  flex-direction: column;
  gap: var(--space-4);
  transition: box-shadow 200ms var(--ease-out), transform 200ms var(--ease-out);
}

.contact-track:hover {
  box-shadow: 0 4px 16px rgba(0,0,0,0.4);
  transform: translateY(-2px);
}

.contact-track.primary {
  background: linear-gradient(135deg, rgba(18,181,195,0.1), rgba(18,181,195,0.04));
  border-color: rgba(18,181,195,0.25);
}

.contact-track-icon {
  width: 48px;
  height: 48px;
  background: var(--color-accent-dim);
  border-radius: var(--radius-lg);
  display: flex;
  align-items: center;
  justify-content: center;
  color: var(--color-accent);
}

.contact-track h3 {
  font-family: var(--font-body);
  font-size: var(--text-base);
  font-weight: 700;
  color: var(--dark-text);
}

.contact-track p {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: var(--dark-text-muted);
  line-height: 1.6;
  max-width: none;
  flex: 1;
}

.contact-email {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--dark-text-muted);
}

@media (max-width: 768px) {
  .investors-intro { grid-template-columns: 1fr; }
  .contact-tracks { grid-template-columns: 1fr; }
}

/* ============================================================
   FOOTER
   ============================================================ */
.footer {
  background: #070E1A;
  border-top: 1px solid rgba(228,236,244,0.06);
  padding-block: var(--space-12) var(--space-8);
  padding-inline: clamp(var(--space-4), 4vw, var(--space-12));
}

.footer-inner {
  max-width: var(--content-wide);
  margin-inline: auto;
}

.footer-top {
  display: grid;
  grid-template-columns: 1.5fr repeat(3, 1fr);
  gap: var(--space-8);
  padding-bottom: var(--space-10);
  border-bottom: 1px solid rgba(228,236,244,0.06);
}

.footer-brand p {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: rgba(228,236,244,0.35);
  line-height: 1.6;
  max-width: 32ch;
  margin-top: var(--space-3);
}

.footer-col h4 {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: rgba(228,236,244,0.4);
  margin-bottom: var(--space-4);
}

.footer-col ul { list-style: none; display: flex; flex-direction: column; gap: var(--space-2); }

.footer-col a {
  text-decoration: none;
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: rgba(228,236,244,0.45);
  transition: color 180ms var(--ease-out);
}
.footer-col a:hover { color: rgba(228,236,244,0.8); }

.footer-bottom {
  display: flex;
  align-items: center;
  justify-content: space-between;
  flex-wrap: wrap;
  gap: var(--space-4);
  padding-top: var(--space-8);
}

.footer-copy {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: rgba(228,236,244,0.25);
}

.footer-social {
  display: flex;
  gap: var(--space-4);
}

.footer-social a {
  display: flex;
  align-items: center;
  justify-content: center;
  width: 36px;
  height: 36px;
  border-radius: var(--radius-full);
  color: rgba(228,236,244,0.3);
  border: 1px solid rgba(228,236,244,0.1);
  text-decoration: none;
  transition: color 180ms var(--ease-out), border-color 180ms var(--ease-out);
}
.footer-social a:hover {
  color: rgba(228,236,244,0.8);
  border-color: rgba(228,236,244,0.3);
}

.footer-disclaimer {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: rgba(228,236,244,0.2);
  line-height: 1.5;
  margin-top: var(--space-6);
  padding-top: var(--space-6);
  border-top: 1px solid rgba(228,236,244,0.05);
  max-width: none;
}

@media (max-width: 768px) {
  .footer-top { grid-template-columns: 1fr 1fr; }
  .footer-brand { grid-column: 1 / -1; }
  .footer-bottom { flex-direction: column; align-items: flex-start; }
}

@media (max-width: 480px) {
  .footer-top { grid-template-columns: 1fr; }
}

/* ============================================================
   SECTION DIVIDERS
   ============================================================ */
.divider {
  height: 1px;
  background: linear-gradient(90deg, transparent, var(--color-accent), transparent);
  opacity: 0.3;
}

/* ============================================================
   SCROLL REVEAL ANIMATIONS
   ============================================================ */
.fade-in {
  opacity: 1;
}

@supports (animation-timeline: scroll()) {
  .fade-in {
    opacity: 0;
    animation: reveal-fade linear both;
    animation-timeline: view();
    animation-range: entry 0% entry 60%;
  }
}

@keyframes reveal-fade {
  to { opacity: 1; }
}

/* ============================================================
   SECTION HEADER PATTERN
   ============================================================ */
.section-header {
  margin-bottom: var(--space-12);
}

.section-header .eyebrow {
  margin-bottom: var(--space-3);
}

.section-header .section-title {
  margin-bottom: var(--space-4);
}

.section-header .section-body {
  max-width: 60ch;
}

/* ============================================================
   MISC UTILITIES
   ============================================================ */
.text-center { text-align: center; }
.text-center .section-body { margin-inline: auto; }

.highlight { color: var(--color-accent); }

/* ============================================================
   SCIENCE SECTION — EVIDENCE COMPONENTS
   ============================================================ */

/* ── Table scroll wrapper ── */
.table-scroll {
  overflow-x: auto;
  -webkit-overflow-scrolling: touch;
  border-radius: var(--radius-lg);
  border: 1px solid var(--color-border);
}

/* Remove double border since .comparison-table already has outer border */
.table-scroll .comparison-table {
  border: none;
  border-radius: 0;
}

/* ── Evidence Highlights bar ── */
.sci-highlights {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: var(--space-4);
  margin-top: var(--space-10);
  margin-bottom: var(--space-12);
}

.sci-highlight {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius-xl);
  padding: var(--space-6) var(--space-5);
  display: flex;
  flex-direction: column;
  gap: var(--space-2);
  box-shadow: var(--shadow-sm);
  transition: box-shadow 200ms var(--ease-out), transform 200ms var(--ease-out);
}

.sci-highlight:hover {
  box-shadow: var(--shadow-md);
  transform: translateY(-2px);
}

.sci-highlight-accent {
  background: var(--color-accent-dim2);
  border-color: rgba(18, 181, 195, 0.22);
}

.sci-highlight-value {
  font-family: var(--font-display);
  font-size: var(--text-xl);
  font-style: italic;
  color: var(--color-accent);
  line-height: 1;
}

.sci-highlight-label {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  font-weight: 600;
  color: var(--color-text);
  line-height: 1.3;
}

.sci-highlight-source {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--color-text-faint);
  line-height: 1.4;
  margin-top: auto;
}

/* ── Section blocks ── */
.sci-block {
  margin-top: var(--space-16);
  padding-top: var(--space-10);
  border-top: 1px solid var(--color-border);
}

.sci-block-label {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 600;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--color-accent);
  margin-bottom: var(--space-6);
}

.sci-block-intro {
  font-family: var(--font-body);
  font-size: var(--text-base);
  color: var(--color-text-muted);
  line-height: 1.7;
  max-width: 72ch;
  margin-bottom: var(--space-8);
}

/* ── Trial Cards ── */
.trial-cards {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: var(--space-6);
  margin-bottom: var(--space-8);
}

.trial-card {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius-xl);
  padding: var(--space-8);
  display: flex;
  flex-direction: column;
  gap: var(--space-4);
  box-shadow: var(--shadow-sm);
  transition: box-shadow 200ms var(--ease-out), transform 200ms var(--ease-out);
}

.trial-card:hover {
  box-shadow: var(--shadow-md);
  transform: translateY(-2px);
}

.trial-card-featured {
  border-color: rgba(18, 181, 195, 0.35);
  background: linear-gradient(
    160deg,
    var(--color-accent-dim2) 0%,
    var(--color-surface) 40%
  );
}

.trial-card-top {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: var(--space-4);
}

.trial-card-meta {
  display: flex;
  flex-direction: column;
  gap: var(--space-2);
}

.trial-card-tag {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--color-text-muted);
  background: var(--color-surface-2);
  padding: 0.2em 0.6em;
  border-radius: var(--radius-full);
  white-space: nowrap;
}

.trial-card-journal {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--color-text-faint);
  font-style: italic;
}

.trial-effect {
  display: flex;
  flex-direction: column;
  align-items: flex-end;
  flex-shrink: 0;
  text-align: right;
}

.trial-effect-label {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 600;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  color: var(--color-text-faint);
  line-height: 1;
  margin-bottom: var(--space-1);
}

.trial-effect-value {
  font-family: var(--font-display);
  font-size: var(--text-xl);
  font-style: italic;
  color: var(--color-accent);
  line-height: 1;
}

.trial-effect-large .trial-effect-value {
  font-size: var(--text-2xl);
}

.trial-card-title {
  font-family: var(--font-body);
  font-size: var(--text-base);
  font-weight: 700;
  color: var(--color-text);
  line-height: 1.4;
  margin: 0;
}

.trial-card-authors {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--color-text-muted);
  font-style: italic;
  margin: 0;
}

.trial-stats {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: var(--space-3);
  margin-top: var(--space-2);
}

.trial-stat {
  background: var(--color-surface-2);
  border-radius: var(--radius-md);
  padding: var(--space-3) var(--space-4);
  display: flex;
  flex-direction: column;
  gap: var(--space-1);
}

.trial-stat-value {
  font-family: var(--font-display);
  font-size: var(--text-lg);
  font-style: italic;
  color: var(--color-text);
  line-height: 1;
}

.trial-stat-label {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--color-text-muted);
  line-height: 1.3;
}

.trial-card-note {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--color-text-muted);
  line-height: 1.6;
  border-top: 1px solid var(--color-border);
  padding-top: var(--space-4);
  margin: 0;
}

/* ── Supporting evidence row ── */
.sci-supporting-row {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: var(--space-6);
}

.sci-support-item {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-left: 3px solid var(--color-accent);
  border-radius: var(--radius-lg);
  padding: var(--space-6);
  display: flex;
  flex-direction: column;
  gap: var(--space-2);
}

.sci-support-label {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--color-accent);
}

.sci-support-title {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  font-weight: 700;
  color: var(--color-text);
  line-height: 1.4;
}

.sci-support-body {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: var(--color-text-muted);
  line-height: 1.6;
  flex: 1;
}

/* ── PK section extras ── */
.sci-table-note {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  color: var(--color-text-faint);
  line-height: 1.6;
  margin-top: var(--space-3);
  margin-bottom: var(--space-6);
}

.sci-insight-box {
  background: var(--color-accent-dim2);
  border: 1px solid rgba(18, 181, 195, 0.25);
  border-left: 4px solid var(--color-accent);
  border-radius: var(--radius-lg);
  padding: var(--space-6) var(--space-8);
  display: flex;
  flex-direction: column;
  gap: var(--space-3);
  margin-top: var(--space-6);
}

.sci-insight-label {
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--color-accent);
}

.sci-insight-box p {
  font-family: var(--font-body);
  font-size: var(--text-sm);
  color: var(--color-text);
  line-height: 1.75;
  margin: 0;
  max-width: none;
}

/* ── Evidence Strength table ── */
.strength-table {
  width: 100%;
  border-collapse: collapse;
  font-family: var(--font-body);
  font-size: var(--text-sm);
  background: var(--color-surface);
}

.strength-table th {
  padding: var(--space-4) var(--space-6);
  text-align: left;
  font-weight: 700;
  font-size: var(--text-xs);
  letter-spacing: 0.05em;
  text-transform: uppercase;
  color: var(--color-text-muted);
  background: var(--color-surface-2);
  border-bottom: 1px solid var(--color-border);
}

.strength-table td {
  padding: var(--space-4) var(--space-6);
  color: var(--color-text);
  border-bottom: 1px solid var(--color-border);
  line-height: 1.5;
  vertical-align: middle;
}

.strength-table tr:last-child td { border-bottom: none; }

.strength-table td:first-child {
  font-weight: 600;
  color: var(--color-text);
}

.strength-table td:last-child {
  font-size: var(--text-xs);
  color: var(--color-text-muted);
}

.strength-table tr:hover td {
  background: var(--color-surface-2);
}

.strength-row-absent td {
  background: rgba(220, 80, 60, 0.04);
}

.strength-row-absent:hover td {
  background: rgba(220, 80, 60, 0.07) !important;
}

/* Evidence strength badges */
.strength-badge {
  display: inline-block;
  font-family: var(--font-body);
  font-size: var(--text-xs);
  font-weight: 700;
  letter-spacing: 0.04em;
  padding: 0.25em 0.65em;
  border-radius: var(--radius-full);
  white-space: nowrap;
}

.strength-strong {
  background: rgba(18, 181, 100, 0.12);
  color: #0d9a5e;
  border: 1px solid rgba(18, 181, 100, 0.22);
}

.strength-moderate {
  background: rgba(210, 140, 20, 0.1);
  color: #a86f00;
  border: 1px solid rgba(210, 140, 20, 0.2);
}

.strength-absent {
  background: rgba(200, 50, 40, 0.08);
  color: #c03228;
  border: 1px solid rgba(200, 50, 40, 0.18);
}

/* ── Science responsive ── */
@media (max-width: 900px) {
  .sci-highlights {
    grid-template-columns: repeat(2, 1fr);
  }

  .trial-cards {
    grid-template-columns: 1fr;
  }

  .sci-supporting-row {
    grid-template-columns: 1fr;
  }
}

@media (max-width: 600px) {
  .sci-highlights {
    grid-template-columns: 1fr 1fr;
    gap: var(--space-3);
  }

  .sci-highlight {
    padding: var(--space-4);
  }

  /* Trial card top: stack vertically on small screens */
  .trial-card-top {
    flex-direction: column;
    gap: var(--space-3);
  }

  .trial-effect {
    align-items: flex-start;
    text-align: left;
    flex-direction: row;
    align-items: center;
    gap: var(--space-3);
  }

  .trial-effect-label {
    margin-bottom: 0;
  }

  .trial-card-tag {
    white-space: normal;
  }

  .trial-stats {
    grid-template-columns: 1fr 1fr;
  }

  .sci-insight-box {
    padding: var(--space-5);
  }

  .strength-table th:last-child,
  .strength-table td:last-child {
    display: none;
  }

  .strength-badge {
    white-space: normal;
    display: inline;
    line-height: 1.5;
  }
}